Retrospective cytogenetic analysis of unstable and stable chromosome aberrations in the victims of radiation accident in Bulgaria

Five occupational workers in an industrial sterilization unit at Stamboliyski Bulgaria were accidentally exposed to a very high specific activity of Cobalt-60 source on June 14, 2011. Initial cytogenetic analysis performed days 2 and 7 after radiation exposure revealed the whole body absorbed doses 5.32 Gy for patient 1, 3.40 2, 2.50 3, 1.91 4 1.24 5 [1]. Here, retrospective multicolor FISH was three patients (patients 3) using blood samples collected over period years from 2012 through 2015. In all patients, cells with stable chromosome aberrations (simple complex translocations) 3–4 folds more than unstable (dicentric, rings excess acentric fragments). corroboration results reported literature, we observed that time dependent decline dicentrics, fragments occurred much rapidly translocations victims. Further, inter-individual variation induced also noticed among The reason increased persistence balanced is not entirely clear but may be attributed certain subsets long-lived T-lymphocytes. follow up studies radiation-exposed victims useful determining extent genomic/chromosomal instability hematopoietic system.